Making a Niche: an in vitro human bone marrow organoid factory for blood

The bone marrow is the ‘factory’ where blood cells are made. The ability to recreate a human bone marrow organ from pluripotent stem cells in the laboratory would improve our ability to make blood stem cells for patients with leukaemia or bone marrow failure who cannot find a matched donor. We can now make all the individual components– blood cells, bone, cartilage, blood vessels and stromal cells. In this project we will assemble these into a functioning human bone marrow organ.