Making a Niche: an in vitro human bone marrow organoid factory for blood

  • Cooley, Jodi (PI)
  • Sadoulet, Bernard (CoPI)
  • Huber, Martin (CoPI)
  • Saab, Tarek (CoPI)
  • Figueroa-feliciano, Enectali (CoPI)
  • Ng, Elizabeth E. (PI)

Project Details

Description

The bone marrow is the ‘factory’ where blood cells are made. The ability to recreate a human bone marrow organ from pluripotent stem cells in the laboratory would improve our ability to make blood stem cells for patients with leukaemia or bone marrow failure who cannot find a matched donor. We can now make all the individual components– blood cells, bone, cartilage, blood vessels and stromal cells. In this project we will assemble these into a functioning human bone marrow organ.

StatusFinished
Effective start/end date1/9/2031/8/23

Funding

  • National Science Foundation: US$980,527.00

ASJC Scopus Subject Areas

  • Electrical and Electronic Engineering
  • Astronomy and Astrophysics
  • Physics and Astronomy(all)
  • Biotechnology
  • Biomedical Engineering

Fingerprint

Explore the research topics touched on by this project. These labels are generated based on the underlying awards/grants. Together they form a unique fingerprint.