Upending the platelet paradigm: Targeting actin-driven membrane budding to modulate platelet production in health and disease

Platelets are the cells in the blood responsible for blood clotting and also contribute to wound healing and fighting infection. In a world first, we discovered how the body produces platelets, overturning a 100-year-old dogma. We will capitalise on our breakthrough to understand the diseases of platelet production, develop new therapies to control platelet levels, and generate new knowledge to overcome scalability problems preventing laboratory-based production of platelets for clinical use.