System Toxicological Approaches to Define Flame Retardant Adverse Outcome Pathways

A team of researchers from Oregon State University and North Carolina State University proposes to conduct the first comprehensive in vivo,structure-activity based toxicity studies of flame retardant chemicals (FRCs), including FRCs that EPA has phased out, FRCs that companies manufacture now, and FRCs that companies have proposed as replacements. We will test the hypothesis that the toxicity of FRCs will be highly dependent on their chemical structure.