Leveraging routinely collected health data to improve early identification of autism and co-occurring conditions

  • Goldstein, Benjamin Alan (Investigador principal)

Detalles del proyecto

Descripción

ABSTRACT – Project 2
The overall goal of the Duke Autism Center of Excellence (ACE) is to use a translational digital health and
computational approach to address the critical need for more effective autism screening tools, objective outcome
measures, and brain-based biomarkers that can be used in clinical trials with young autistic children. This Project
will develop and evaluate a novel digital health approach to autism screening. Universal autism screening is
recommended for children at 18 months. This is typically achieved via a caregiver questionnaire. However,
research has shown that a commonly used autism screening questionnaire has reduced accuracy when used in
real-world settings, such as primary care. By leveraging health data related to early medical conditions collected
as part of clinical care, Project 2 aims to develop an automatic, objective tool for autism prediction at 18 months
that can be implemented in primary care settings. We will use routinely collected health data to develop a
prediction model for autism and use the model to design a clinical decision support tool for providers that can be
integrated into pediatric primary care and includes actionable guidance regarding referrals and linkage to
services. We will first develop and validate a generalizable, off-the-shelf model to predict autism for use at 18
months of age using longitudinal claims data (Medicaid and Blue Cross Blue Shield) from a diverse sample of
children across North Carolina with continuous coverage from birth to age 6 years (N ~ 230,000) to predict
likelihood of an autism diagnosis (N ~ 6,000). We will then adapt the autism prediction model to the Duke
University Health System (DUHS) clinical environment and augment it with granular electronic health record
(EHR) data by using machine learning-based natural language processing to embed provider notes. Through
engagement with stakeholders both within and outside of DUHS and in collaboration with Project 1, we will use
the prediction model to design a clinical decision support prototype that could assist providers in making
appropriate and timely referrals. Through the design process, we will identify a set of key priority factors to
consider when choosing a clinical decision support for autism screening that are applicable across a broad range
of stakeholders in different health care settings. Finally, leveraging our robust data on early health encounters,
we will describe the nature and prevalence of patterns of medical conditions during early life. We will test the
specific hypothesis that gastrointestinal problems during early life are associated with higher rates of psychiatric
conditions by age 6.
EstadoFinalizado
Fecha de inicio/Fecha fin6/9/2231/8/23

Financiación

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development: USD234,713.00

!!!ASJC Scopus Subject Areas

  • Psiquiatría y salud mental

Huella digital

Explore los temas de investigación que se abordan en este proyecto. Estas etiquetas se generan con base en las adjudicaciones/concesiones subyacentes. Juntos, forma una huella digital única.