Project Details
Description
Lung squamous cell carcinoma (LUSC) remains one of the most common cancers worldwide with
a dismal prognosis and limited therapies. Recent DNA sequencing results of large numbers of
LUSCs have revealed frequent changes in the NFE2L2 (NRF2) signaling pathway in these
cancers. Identifying key protein kinases that regulate the activity of NRF2 signaling will lead to
new targeted therapies and the development of appropriate models of the disease.
a dismal prognosis and limited therapies. Recent DNA sequencing results of large numbers of
LUSCs have revealed frequent changes in the NFE2L2 (NRF2) signaling pathway in these
cancers. Identifying key protein kinases that regulate the activity of NRF2 signaling will lead to
new targeted therapies and the development of appropriate models of the disease.
| Status | Finished |
|---|---|
| Effective start/end date | 1/12/17 → 30/11/22 |
| Links | https://projectreporter.nih.gov/project_info_details.cfm?aid=10296668 |
ASJC Scopus Subject Areas
- Cancer Research
- Oncology
- Pulmonary and Respiratory Medicine
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