Project Details
Description
The Division of Intramural Population Health Research (DIPHR) at the Eunice Kennedy Shriver
National Institute of Child Health & Human Development (NICHD) designs and conducts original
epidemiological, behavioral, and biostatistical research encompassing several research domains such
as human reproduction and development, pregnancy and related complications, pediatric and
adolescent health and behaviors, and methodologic research relevant for our mission. The Division
comprises three intramural research branches, Epidemiology, Biostatistics & Bioinformatics, and
Social and Behavioral Sciences, and its mission is to design and implement original research with
the potential for high impact findings that impact public health.
Under the developmental origins of health and disease (DOHaD) hypothesis, early life exposures can
“program” an individual for health and chronic disease risk through cellular adaptations to
biological processes. Prenatal exposures and genetic factors impact fetal growth and development
and neonatal health, important determinants of life-long health and disease. We propose an approach
to examine a) the father’s role, b) placental determinants, and c) timing of delivery in relation
to fetal and neonatal health and development. A cohort study will be performed to collect common
data elements from approximately 10,728 pregnant women and their neonates and approximately 3825
male partners with a randomized trial conducted in women with gestational diabetes (approximately
3450 women, an addition of 2730). African American women will be oversampled (~4250). It is anticipated that multiple
study sites will be established.
National Institute of Child Health & Human Development (NICHD) designs and conducts original
epidemiological, behavioral, and biostatistical research encompassing several research domains such
as human reproduction and development, pregnancy and related complications, pediatric and
adolescent health and behaviors, and methodologic research relevant for our mission. The Division
comprises three intramural research branches, Epidemiology, Biostatistics & Bioinformatics, and
Social and Behavioral Sciences, and its mission is to design and implement original research with
the potential for high impact findings that impact public health.
Under the developmental origins of health and disease (DOHaD) hypothesis, early life exposures can
“program” an individual for health and chronic disease risk through cellular adaptations to
biological processes. Prenatal exposures and genetic factors impact fetal growth and development
and neonatal health, important determinants of life-long health and disease. We propose an approach
to examine a) the father’s role, b) placental determinants, and c) timing of delivery in relation
to fetal and neonatal health and development. A cohort study will be performed to collect common
data elements from approximately 10,728 pregnant women and their neonates and approximately 3825
male partners with a randomized trial conducted in women with gestational diabetes (approximately
3450 women, an addition of 2730). African American women will be oversampled (~4250). It is anticipated that multiple
study sites will be established.
| Status | Finished |
|---|---|
| Effective start/end date | 1/10/17 → 30/9/20 |
| Links | https://reporter.nih.gov/project-details/10271530 |
ASJC Scopus Subject Areas
- Pediatrics, Perinatology, and Child Health
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