Postdoctoral Training in Reproductive Mood Disorders

PROJECT SUMMARY
The purpose of the proposed training program, “Postdoctoral Training in Reproductive Mood Disorders” is to
develop researchers with expertise in both the biological basis and clinically relevant (predictive) phenotypes of
reproductive mood disorders (peripubertal depression, perinatal depression, premenstrual dysphoric disorder,
and perimenopausal depression). This is a two-to-three year training program for MD, PhD and MD/PhD
trainees. Training will involve a broad-based and integrative perspective, involving not only psychiatry but
genetics, endocrinology, neuroscience, and obstetrics/gynecology.
With this program’s emphasis on training in pathophysiological mechanisms that underlie reproductive mood
disorders, trainees will develop mastery in the following: reproductive hormonal physiology and signaling;
methods for manipulating the reproductive system; and clinical phenomenology of reproductive mood
disorders. Additionally, trainees will develop expertise in at least one of three methodological training tracks:
Neurosciences, Genetics, or Stress Physiology. Fellows will have a primary research mentor (representing
their training track) and a secondary mentor (from a different track), thereby providing additional exposure to
both the interdisciplinarity and collaborative nature of science. In addition to experiential opportunities with
program faculty, didactics will be tailored to the individual Fellow to ensure that each achieves competence in
their chosen research track. A key element of the training as well includes an independent research project.
Thus, while the training plan is multidisciplinary, an emphasis is placed on individualizing the training
experience for the Fellows. However, through a number of program specific venues designed to bring the
Fellows together for exchange of ideas and support, the program will ensure cohesiveness among the
trainees. Fellows who complete this program will be poised to become independent researchers, having the
unique requisite foundation to examine biobehavioral mechanisms in reproductive mood disorders and the
ability to identify therapeutic biologic targets in their future independent research.
The University of North Carolina at Chapel Hill represents an ideal setting for the proposed program because it
possesses a well-known collaborative infrastructure, a vibrant women’s mood disorder clinical program (which
includes the first inpatient perinatal depression program in the country), and a critical mass of researchers in
reproductive mood disorders with a track record of success.