Mechanism of APE1 in DNA damage response

  • Yan, Shan S (PI)

Project Details

Description

Project Narrative
This project uses frog egg extracts and mammalian cell systems to better understand how oxidative
stress is sensed and signaled for a checkpoint response. By understanding the mechanisms of oxidative
stress signaling, we can better learn how cancer and neurodegenerative disorders develop following
oxidative stress, and ultimately treat these diseases via modulating the distinct checkpoint mechanism.
StatusFinished
Effective start/end date13/2/1831/1/23

Funding

  • National Cancer Institute: US$345,910.00
  • National Cancer Institute: US$324,309.00
  • National Cancer Institute: US$341,830.00
  • National Cancer Institute: US$55,801.00
  • National Cancer Institute: US$422,451.00
  • National Cancer Institute: US$360,794.00
  • National Cancer Institute: US$32,306.00

ASJC Scopus Subject Areas

  • Oncology

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