UNC Kenan-Flagler

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  Preventing Incident Knee Osteoarthritis: The Osteoarthritis Prevention Study (TOPS)

  Messier, S. P. (PI)

  National Institute of Arthritis and Musculoskeletal and Skin Diseases

  1/4/20 → 31/3/21

  Project: Research Project

  • Osteoarthritis Prevention 100%
  • Osteoarthritis 100%
  • Knee Osteoarthritis 50%
  • Disease 42%
  • Inflammation 28%

• CoPe: RCN: Building a Collaboratory for Coastal Adaptation over Space and Time (C-CoAST)

  Moore, L. (PI), Luettich, R. R. A. (CoPI), Mcnamara, D. (CoPI), Mullin, M. M. (CoPI) & Smith, M. D. (CoPI)

  National Science Foundation

  1/4/20 → 31/3/23

  Project: Research Project

  • Grand Challenge 100%
  • Network Activity 50%
  • Natural System 50%
  • Research Agenda 50%
  • Sociology 50%

• AGROECOLOGY SCHOLARS PROGRAM IN RESEARCH AND EXTENSION (ASPIRE) FOR DIVERSITY

  Cruz, A. E. A. E. (PI)

  National Institute of Food and Agriculture

  1/4/20 → 31/3/24

  Project: Research Project

  • Scholar Programs 100%
  • Professional Development Training 33%
  • Agricultural Workforce 33%
  • Main Activities 33%
  • North Carolina 33%

• Expoitation of ER Stress Induced Immune Dysfunction to Improve Immunotherapy

  Thaxton, J. (CoPI) & Thaxton, J. J. E. (PI)

  1/4/20 → 31/3/24

  Project: Research Project

  • T Cell 100%
  • CD-8 66%
  • Tumor-infiltrating Lymphocytes 66%
  • OT-1 33%
  • Metabolic Pathway 33%

• Microfabricated all-diamond microelectrode arrays for neurotransmitter sensing and extracellular recording

  Li, W. W. (PI)

  National Institute of Neurological Disorders and Stroke

  1/4/20 → 31/1/24

  Project: Research Project

  • Diamond Microelectrodes 100%
  • Neural Interface 44%
  • Encapsulation Materials 33%
  • Materials Synthesis 33%
  • Compact Dual 33%

• Molecular profiling of medullary descending pain modulation circuits to discover novel analgesic targets

  Scherrer, G. (CoPI)

  1/4/20 → 30/6/20

  Project: Research Project

  • Rostral Ventrolateral Medulla 100%
  • Single-cell RNA Sequencing (scRNA-seq) 16%
  • Control System 11%
  • Descending Control 11%
  • Brainstem 11%

• Core-Shell Oxidative Aromatization Catalysts for Single Step Liquefaction of Distributed Shale Gas

  Li, F. F. (PI)

  National Energy Technology Laboratory

  1/4/20 → 30/6/23

  Project: Research Project

• A novel diabetic co-infection model to study pathogen interaction during co-infection

  Thurlow, L. R. (CoPI)

  19/3/20 → 28/2/21

  Project: Research Project

  • Infectious Agent 100%
  • Microenvironment 13%
  • Diabetic Skin 6%
  • Diabetic Environment 6%
  • Airway 6%

• AIM BACK UH3 Transition

  George, S. Z. (PI)

  National Center for Complementary and Integrative Health

  18/3/20 → 29/2/24

  Project: Research Project

  • Pain Interference 75%
  • Nonpharmacological Pain Management 66%
  • Electronic Health Record 37%
  • Non-pharmacological Therapy 33%
  • Physical Pain 33%

• Molecular Biotechnology Laboratory Education Modules (MBLEM)

  Kelly, R. R. M. (PI) & Goller, C. C. C. (CoPI)

  National Institute of General Medical Sciences

  15/3/20 → 29/2/24

  Project: Research Project

  • Outreach 50%
  • North Carolina 23%
  • Educational Mission 16%
  • New Pedagogical Approaches 16%
  • Biomedical Workforce 15%

• Collaborative Research: Tracing Coal Ash Solids in the Environment - Implications for long-term contamination of the aquatic ecosystem

  Cowan, E. E. A. (PI) & Brachfeld, S. S. A. (CoPI)

  National Science Foundation

  1/3/20 → 28/2/23

  Project: Research Project

  • Aquatic Ecosystems 50%
  • Media Communication 16%
  • Decommissioning 16%
  • North Carolina 9%
  • Radioactive Isotope 8%

• Collaborative Research: Tracing Coal Ash Solids in the Environment - Implications for long-term contamination of the aquatic ecosystem

  Vengosh, A. A. (PI)

  National Science Foundation

  1/3/20 → 28/2/23

  Project: Research Project

  • Aquatic Ecosystems 100%
  • North Carolina 18%
  • Media Communication 16%
  • Radioactive Isotope 16%
  • Magnetic Permeability 16%

• Center for Environmental and Health Effects of PFAS

  Mattingly, C. J. (PI), Knappe, D. D. R. (CoPI), Griffith, E. E. H. (CoPI), Baker, E. E. M. (CoPI), Baker, E. E. S. (CoPI), Hoppin, J. J. (CoPI), Knappe, D. R. (CoPI), Kullman, S. W. (CoPI), May, K. (CoPI), Muddiman, D. C. (CoPI), Planchart, A. J. (CoPI), Ranjithan, R. R. S. (CoPI) & Reif, D. M. (CoPI)

  National Institute of Environmental Health Sciences

  28/2/20 → 31/1/24

  Project: Research Project

  • Health Effects 80%
  • Polyfluoroalkyl Substances 80%
  • State of the Art 36%
  • North Carolina 22%
  • Superfund 15%

• PM exposure and changes in respiratory host defense responses

  Jaspers, I. I. (PI) & Alexis, N. E. (CoPI)

  National Institute of Environmental Health Sciences

  24/2/20 → 31/8/24

  Project: Research Project

  • PM Exposure 100%
  • China 75%
  • Sputum 62%
  • Airway 52%
  • Sputum Samples 47%

• Image-guided, ultrasound-enhanced long-term intracranial drug delivery

  Brudno, Y. Y. (PI) & Dayton, P. A. (CoPI)

  National Cancer Institute

  15/2/20 → 31/1/22

  Project: Research Project

  • Ultrasound-enhanced 66%
  • Blood-Brain Barrier 66%
  • Blood-brain Barrier 47%
  • Side Effect 33%
  • Drug Delivery Strategies 19%

• The impact of obesity on cerebral glucose transport and metabolism

  Hwang, J. J. J. (PI)

  7/2/20 → 31/1/24

  Project: Research Project

  • Metabolic Pathway 100%
  • Cerebral Metabolism 16%
  • Blood-brain Barrier 16%

• ECOLOGY AND SYSTEMATICS OF FRESHWATER FISHES

  Stauffer, J. J. (PI)

  National Institute of Food and Agriculture

  1/2/20 → 31/12/24

  Project: Research Project

  • Freshwater Fish 100%
  • Ordovician 50%
  • Coastal Plain 37%
  • Salvelinus 25%
  • Center of Origin 25%

• The pig: A novel large animal model of allergic eosinophilic esophagitis

  Kaeser, T. E. (PI) & Laster, S. M. (CoPI)

  National Institute of Allergy and Infectious Diseases

  1/2/20 → 31/1/22

  Project: Research Project

  • Eosinophilic Esophagitis 100%
  • Food Allergy 60%
  • Esophagus 20%
  • Multidisciplinary Team 10%
  • Clinical Treatment 10%

• Collaborative Research: Novel neurocognitive assessment of engineering education interventions applied to systems thinking

  Gero, J. J. S. (PI)

  National Science Foundation

  1/2/20 → 31/1/23

  Project: Research Project

  • Priming 100%
  • Brain Imaging 14%
  • Conceptual Diagram 14%
  • Concept Mapping 14%
  • Dynamic Relationship 7%

• Tolerising antigen-specific immunotherapy for type 1 diabetes

  Kuila, D. (PI), Basha, O. M. (CoPI) & Hamilton-williams, E. E. (PI)

  National Science Foundation

  1/2/20 → 31/5/21

  Project: Research Project

  • Hydrocarbons 100%
  • I-Corps 100%
  • Residence Time 20%
  • Chemical Engineering 20%
  • CO2 Conversion 20%

• A Common Dialect for Infrastructure and Services in Translator

  Bizon, C. (CoPI), Haendel, M. A. (CoPI), Mungall, C. J. (CoPI), Brush, M. H. (PI), Thessen, A. A. E. (CoPI), Mungall, C. C. J. (CoPI) & Bizon, C. (CoPI)

  23/1/20 → 30/11/24

  Project: Research Project

  • Ontology 100%
  • Knowledge Provider 23%
  • Communication Protocol 20%
  • Modeling Perspectives 7%
  • Additional Service 7%

• Understanding and Addressing Racial Disparities in Guideline-Indicated Management of Symptomatic Peripheral Artery Disease

  Kalbaugh, C. C. A. (CoPI)

  National Heart, Lung, and Blood Institute

  15/1/20 → 31/12/23

  Project: Research Project

  • Healthcare 35%
  • Vascular Quality Initiative 30%
  • Method in Epidemiology 20%
  • Medicine 20%
  • Epidemiologist 20%

• Collaborative Research: ABI Development: Integrated platforms for protein structure and function predictions

  Kc, D. D. B. (PI)

  National Science Foundation

  7/1/20 → 30/6/21

  Project: Research Project

  • Integrated Platform 100%
  • Protein Modeling 66%
  • Structure-based Function Annotation 66%
  • Parallel Computing 50%
  • High-Performance Computing 50%

• NSF Convergence Accelerator Track J: Accelerating commercial marine fish production in US: developing sustainable feeds, establishing feed suppliers and enhancing market acceptance

  Watanabe, W. O. (CoPI), Carroll, P. (CoPI) & Alam, M. S. (PI)

  National Science Foundation

  6/1/20 → 30/11/23

  Project: Research Project

  • Market Acceptance 100%
  • Salicornia 50%
  • Eco-costs 25%
  • Essential nutrients 25%
  • Product Derivation 25%

• CRCE and Related Activities Core

  Blobe, G. C. (PI), Blobe, G. G. C. (PI) & Antonia, S. J. (PI)

  National Cancer Institute

  1/1/20 → 31/12/23

  Project: Research Project

  • Medicine 36%
  • Accreditation Council for Graduate Medical Education (ACGME) 33%
  • University Health 25%
  • Postgraduate Programs 16%
  • Medical Scientist Training Program 16%

• Launching a food justice think tank of community organizers and researchers to address food system inequities

  Brownell, K. K. (PI), Zuckerman, J. J. (CoPI), Lampron, E. A. E. A. (PI) & Limited, C. (CoI)

  1/1/20 → 14/12/23

  Project: Research Project

  • Inequity 100%
  • Justice 100%
  • Leading Organizations 33%
  • Academic Research 33%
  • Local Food Systems 33%

• Analytical pipelines for data and model integration: finding informed pathways for antimicrobial resistance control

  Lanzas, C. (PI)

  National Institute of General Medical Sciences

  1/1/20 → 31/12/23

  Project: Research Project

  • Infectious Agent 100%
  • Antimicrobial Resistance 100%
  • Resistance Control 66%
  • Analytical pipeline 66%
  • Agent-based Model 50%

• Framework: Sofware: Collaborative Research: CyberWater -An open and sustainable framework for diverse data and model integration with provenance and access to HPC

  Zhang, Y. Y. (PI)

  National Science Foundation

  1/1/20 → 31/12/23

  Project: Research Project

  • Sustainable Framework 100%
  • Research Community 100%
  • User Workflow 50%
  • Water-related 50%
  • Environment Modeling 50%

• Role of Ankyrin-B in the Nervous System

  Lorenzo, D. N. (CoPI) & Lorenzo, D. D. N. (PI)

  1/1/20 → 31/12/23

  Project: Research Project

  • Axon Guidance 11%
  • Molecular Interactions 11%
  • Pathophysiology 11%
  • Cultured Neurons 11%
  • Neuronal Loss 11%

• Correction of endocrine disruptor-induced transgenerational epimutations by CRISPR-dCas9

  Bhandari, R. K. (PI)

  National Institute of Child Health and Human Development

  15/12/19 → 30/11/21

  Project: Research Project

  • Endocrine Disruptors 100%
  • CRISPR 50%
  • Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) 13%
  • Primordial Germ Cells 9%
  • F3 Generation 9%

• Cell-Mediated Targeted Redox Intervention for the Treatment and Prevention of Atherosclerosis

  Bahnson, E. E. M. (PI)

  National Heart, Lung, and Blood Institute

  15/12/19 → 30/11/23

  Project: Research Project

  • Atherosclerosis 100%
  • Transcription Factor Nrf2 80%
  • Nanoparticle 53%
  • Drug Delivery 46%
  • Inflammation 26%

• Manipulation of MHC expression using TGF-beta2 to reduce mesenchymal stem cell immunogenicity

  Berglund, A. K. (PI)

  NIH Office of the Director

  15/12/19 → 30/11/23

  Project: Research Project

  • Major Histocompatibility Complex 80%
  • Immunogenicity 80%
  • Murine Model 16%
  • Response Spectrum Analysis 12%
  • Genetic Transcription 11%

• Identification of a central player in neoplastic transformation of intestinal stem cells:protocadherin 8

  Van Landeghem, L. L. C. (PI)

  National Cancer Institute

  10/12/19 → 30/11/21

  Project: Research Project

  • Genetic Signaling 18%
  • Carcinogenesis 12%
  • Cancer Cell 12%
  • Evolutionary Fitness 6%
  • Intestinal Health 6%

• Identifying structural differences between fibrinogen and fibrin to provide novel therapeutic targets

  Offenbacher, A. (PI)

  National Heart, Lung, and Blood Institute

  1/12/19 → 30/11/22

  Project: Research Project

  • Novel Therapeutic Targets 100%
  • Fibrinogen 100%
  • Fibrin Polymerization 23%
  • Glycosylation 23%
  • Radiation Scattering 15%

• Jim Crow in the Asylum: Psychiatry and Civil Rights in the American South

  Smith, K. K. (PI)

  U.S. National Library of Medicine

  1/12/19 → 30/11/22

  Project: Research Project

  • Psychiatry 66%
  • Alabama 53%
  • Civil Rights Act 41%
  • Desegregation 33%
  • Mental Health Service Provision 33%

• TAK1 Inhibition by (5Z)-7-Oxozeaenol Analogues for Anticancer Leads

  Croatt, M. P. (PI)

  National Cancer Institute

  1/12/19 → 30/11/22

  Project: Research Project

  • 5Z-7-oxozeaenol 100%
  • Cancer Cell 100%
  • Crystal Structure 100%
  • TAK1 50%
  • Lactone 50%

• Computational and experimental insights into the structure and dynamics of heterochromatin

  Kireev, D. D. (CoPI) & Hathaway, N. N. A. (CoPI)

  1/12/19 → 30/11/23

  Project: Research Project

  • Dynamics 100%
  • Derepression 25%
  • One Step Forward 14%
  • Chromosome Conformation Capture 14%
  • Associated Proteins 14%

• EAGER: Lambda-Red-enhanced homologous recombination in plants

  Alonso, J. J. M. (PI) & Stepanova, A. A. N. (CoPI)

  National Science Foundation

  1/12/19 → 30/11/23

  Project: Research Project

  • Homologous Recombination 50%
  • DNA Template 25%
  • Large Insertion 16%
  • Biological Knowledge 16%
  • Viral Replicons 16%

• Uncovering the Mechanisms of PFAS-induced Immunotoxicity

  Kullman, S. W. (PI) & Kullman, S. S. W. (PI)

  National Institute of Environmental Health Sciences

  1/12/19 → 31/1/24

  Project: Research Project

  • Immunotoxicity 75%
  • Polyfluoroalkyl Substances 75%
  • Mouse Model 22%
  • North Carolina 7%
  • In Vitro Cell Models 5%

• Optimal Use of Grid-Connected Energy Storage to Reduce Human Health Impacts

  Johnson, J. J. (PI), Garcia Menendez, F. F. G. (CoPI), Fell, H. H. (CoPI) & Morrill, M. M. S. (CoPI)

  National Science Foundation

  15/11/19 → 31/10/23

  Project: Research Project

  • Level Unit 28%
  • Spatially Resolved 16%
  • NOx Emission 16%
  • Sulfur Dioxide SO2 16%
  • Temporally Resolved 16%

• SHF:Small:Collaborative Research: Application-aware Energy Modeling and Power Management for Parallel and High Performance Computing

  Yan, Y. Y. (PI)

  National Science Foundation

  15/10/19 → 30/9/20

  Project: Research Project

  • Parallel Performance 50%
  • High-Performance Computing 50%
  • Enterprise Computing Systems 40%
  • Tuning Performance 20%
  • System Efficiency 20%

• DIVERSIFYING TREE HOST RANGE FOR SUSTAINABLE PRODUCTION OF BIANCHETTO TRUFFLES- TUBER BORCHII

  Isikhuemhen, O. S. O. M. S. (PI)

  National Institute of Food and Agriculture

  1/10/19 → 30/9/22

  Project: Research Project

  • Truffle 100%
  • Seedling Growth 16%
  • Ecological Niche 14%
  • Plant Growth 8%
  • Suitable Host 7%

• RI: Small: Principles of Normative Multiagent Systems for Decentralized Applications

  Singh, M. M. P. (PI)

  National Science Foundation

  1/10/19 → 30/9/23

  Project: Research Project

  • Normative multi-agent Systems 100%
  • Interoperation 50%
  • User Autonomy 50%
  • Gain in Efficiency 50%
  • Multiple Agents 50%

• CHARACTERIZING AND IMPROVING HUMANIZED IMMUNE SYSTEM MOUSE MODELS (IMM-HIS)

  Garcia-martinez, V. J. (PI)

  1/10/19 → 30/9/20

  Project: Research Project

  • Infectious Diseases 50%

• SHF: Small: Collaborative Research: Efficient Memory Persistency for GPUs

  Zhou, H. H. (PI)

  National Science Foundation

  1/10/19 → 30/9/23

  Project: Research Project

  • Memory Capacity 20%
  • High-Performance Computing 20%
  • Outreach Activity 20%
  • Application Domain 20%
  • Computer System 20%

• Preparing Academically Talented Students with Financial Need to be the Next Generation of Engineering Professionals by Fostering Innovation and Leadership Skills

  Stanfield, P. P. M. (PI), Ram, B. B. (CoPI), Williams, M. M. F. (CoPI), Powell, R. R. L. (CoPI) & Mccullough, M. M. (CoPI)

  National Science Foundation

  1/10/19 → 30/9/24

  Project: Research Project

  • Fostering Innovation 100%
  • Academically Gifted 50%
  • Science, Technology, Engineering and Mathematics 50%
  • Engineering Leadership 25%
  • Leadership Development 25%

• DEVELOPMENT OF POTATO VARIETIES FOR THE MID-ATLANTIC AND SOUTHEASTERN US

  Yencho, G. G. E. (PI)

  National Institute of Food and Agriculture

  1/10/19 → 30/9/24

  Project: Research Project

  • USDA 50%
  • University of Michigan 33%
  • Agricultural Research 33%
  • Processing Quality 33%
  • Breeding Strategy 33%

• Integrating Human Wearers' Perception and Cognition into Prosthesis Control Policy

  Huang, H. H. (PI) & Feng, J. J. (CoPI)

  National Science Foundation

  1/10/19 → 30/9/23

  Project: Research Project

  • Functional Part 33%
  • Prosthesis 16%
  • Underrepresented Minority 16%
  • Robot 16%
  • Cognitive Level 11%

• RI: Small: Information-theoretic Multiagent Paths for Anticipatory Control of Tasks (IMPACT)

  Pandey, V. (PI)

  National Science Foundation

  1/10/19 → 30/9/23

  Project: Research Project

  • Robot 100%
  • Tasks 100%
  • Route Planning 60%
  • Multi-agent 50%
  • Autonomous Driving 40%

• CAREER: Programming the Existing and Emerging Memory Systems for Extreme-scale Parallel Performance

  Yan, Y. Y. (PI)

  National Science Foundation

  1/10/19 → 31/1/23

  Project: Research Project

  • Parallel Performance 100%
  • Memory Wall 50%
  • High-Performance Computing 50%
  • Innovative Computing 25%
  • Execution Model 25%